Grade B
Rct
Caloric Restriction and Epigenetic Age: CALERIE-2 Results
Analysis of CALERIE-2 trial examining 25% caloric restriction effects on epigenetic aging clocks over 2 years in non-obese adults.
Published 2023
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DOI: 10.1038/s43587-023-00345-y
[STUDY DETAILS]
- Study Type
- Rct
- Quality Grade
- B
- Publication Year
- 2023
- Category
- Longevity & Aging
Summary
CALERIE-2 (n=220) found 25% caloric restriction slowed epigenetic aging by 2-3% per year measured by DunedinPACE clock. This translates to 10-15% reduced mortality risk.
Key Findings
1. Epigenetic aging slowed 2-3% annually
2. Estimated 10-15% mortality reduction
3. Benefits sustained over 2 years
4. No adverse effects on bone or muscle