// KNOWLEDGE_BASE
HEALTH & LONGEVITY GLOSSARY
Evidence-based definitions for fitness metrics, biomarkers, and training concepts.
Recovery & Adaptation
5 terms
Active Recovery
Well-EstablishedLow-intensity exercise performed to promote recovery rather than create training stress.
Delayed Onset Muscle Soreness
Well-EstablishedMuscle pain and stiffness that develops 24-72 hours after unaccustomed or intense exercise.
Overtraining Syndrome
Well-EstablishedA condition of decreased performance and fatigue that occurs when training exceeds recovery capacity for an extended period.
Sleep Quality
Well-EstablishedA measure of how well sleep restores and recovers the body, beyond simple sleep duration.
Supercompensation
Well-EstablishedThe training principle where fitness improves above baseline during recovery from training stress.
Longevity & Aging
5 terms
Autophagy
Emerging ResearchA cellular process where damaged components are recycled, playing a key role in cellular health and longevity.
mTOR
Emerging ResearchA cellular signaling pathway that regulates growth and metabolism, with implications for aging and disease.
NAD+
Emerging ResearchA coenzyme essential for cellular energy production that declines with age, involved in DNA repair and longevity pathways.
Senescent Cells
Emerging ResearchCells that have stopped dividing but remain metabolically active, secreting inflammatory factors that contribute to aging.
Telomeres
Emerging ResearchProtective caps at the ends of chromosomes that shorten with each cell division, serving as a marker of biological aging.
Mental Performance
5 terms
BDNF
Well-EstablishedA protein that supports brain cell growth, survival, and plasticity, crucial for learning, memory, and mental health.
Cognitive Reserve
Well-EstablishedThe brain's resilience to damage or decline, built through education, mental stimulation, and social engagement.
Focus
Well-EstablishedThe cognitive ability to concentrate attention on a task while ignoring distractions.
Neuroplasticity
Well-EstablishedThe brain's ability to reorganize itself by forming new neural connections throughout life.
Working Memory
Well-EstablishedThe cognitive system that temporarily holds and manipulates information for complex tasks like reasoning and learning.
Metabolic Health
5 terms
Blood Glucose
Well-EstablishedThe concentration of glucose (sugar) in the blood, a critical marker of metabolic health and energy regulation.
HbA1c
Well-EstablishedA blood test measuring average blood sugar levels over the past 2-3 months by showing the percentage of hemoglobin bound to glucose.
Insulin Sensitivity
Well-EstablishedHow effectively your cells respond to insulin to take up glucose from the bloodstream.
Ketosis
Emerging ResearchA metabolic state where the body primarily burns fat for fuel, producing ketone bodies as an alternative energy source to glucose.
Metabolic Rate
Well-EstablishedThe rate at which your body burns calories at rest to maintain basic life functions.
Cardiovascular Health
5 terms
Blood Pressure
Well-EstablishedThe force of blood pushing against artery walls, measured as systolic (heart pumping) over diastolic (heart resting) pressure.
Heart Rate Variability
Well-EstablishedThe variation in time between consecutive heartbeats, a key indicator of autonomic nervous system function and overall health.
Resting Heart Rate
Well-EstablishedThe number of heartbeats per minute while at complete rest, typically measured upon waking.
Stroke Volume
Well-EstablishedThe amount of blood pumped by the left ventricle with each heartbeat.
VO2 Max
Well-EstablishedThe maximum rate of oxygen consumption during intense exercise, a gold-standard measure of cardiovascular fitness.
Sleep Science
5 terms
Circadian Rhythm
Well-EstablishedThe roughly 24-hour internal biological clock that regulates sleep-wake cycles, hormone release, and other physiological processes.
Deep Sleep
Well-EstablishedThe most restorative sleep stage characterized by slow brain waves, essential for physical recovery, immune function, and growth hormone release.
REM Sleep
Well-EstablishedA sleep stage characterized by rapid eye movements, vivid dreaming, and muscle paralysis, critical for memory consolidation and emotional processing.
Sleep Efficiency
Well-EstablishedThe percentage of time spent actually sleeping versus total time in bed, a key indicator of sleep quality.
Sleep Latency
Well-EstablishedThe time it takes to transition from full wakefulness to sleep after getting into bed with the intention to sleep.
Hormones & Endocrine
5 terms
Cortisol
Well-EstablishedThe primary stress hormone that regulates metabolism, immune response, and the body's fight-or-flight response.
Growth Hormone
Well-EstablishedA hormone that stimulates growth, cell reproduction, and regeneration, playing key roles in body composition and metabolism.
Insulin
Well-EstablishedA hormone produced by the pancreas that regulates blood sugar by promoting glucose uptake into cells.
Testosterone
Well-EstablishedThe primary male sex hormone responsible for muscle mass, bone density, libido, and overall vitality in both sexes.
Thyroid Hormones
Well-EstablishedHormones produced by the thyroid gland that regulate metabolism, energy, body temperature, and growth.
Inflammation & Immunity
5 terms
C-Reactive Protein
Well-EstablishedA blood protein produced by the liver that increases in response to inflammation, used as a marker of systemic inflammation.
Cytokines
Well-EstablishedSignaling proteins released by cells that regulate immunity, inflammation, and cell communication throughout the body.
Gut Microbiome
Emerging ResearchThe complex community of microorganisms living in the digestive tract that influences digestion, immunity, and overall health.
Omega-3 Index
Well-EstablishedA measure of omega-3 fatty acid levels in red blood cell membranes, reflecting long-term omega-3 status and cardiovascular risk.
White Blood Cell Count
Well-EstablishedThe number of white blood cells in the blood, indicating immune system activity and infection-fighting capacity.
Nutrition & Diet
5 terms
Essential Amino Acids
Well-EstablishedThe nine amino acids that cannot be made by the body and must be obtained through diet.
Glycemic Index
Well-EstablishedA scale that ranks carbohydrates based on how quickly they raise blood sugar levels compared to pure glucose.
Macronutrients
Well-EstablishedThe three main nutrients that provide energy: carbohydrates, proteins, and fats.
Protein Synthesis
Well-EstablishedThe cellular process of building new proteins, particularly muscle proteins, in response to exercise and nutrition.
Time-Restricted Eating
Emerging ResearchAn eating pattern where food consumption is limited to a specific time window each day, typically 8-12 hours.
Fitness Metrics
5 terms
Lactate Threshold
Well-EstablishedThe exercise intensity at which lactate accumulates in the blood faster than it can be cleared, marking the transition from sustainable to unsustainable effort.
One Rep Max
Well-EstablishedThe maximum weight you can lift for a single repetition with proper form, used to measure and program strength training.
Rate of Perceived Exertion
Well-EstablishedA subjective scale used to rate how hard exercise feels, from very light to maximum effort.
Training Volume
Well-EstablishedThe total amount of work performed in training, typically calculated as sets x reps x weight.
Zone 2 Training
Well-EstablishedLow to moderate intensity cardio training that maximizes fat oxidation and builds aerobic base without accumulating significant fatigue.