mTOR
Also known as: Mechanistic Target of Rapamycin, mTOR Pathway
A cellular signaling pathway that regulates growth and metabolism, with implications for aging and disease.
FULL EXPLANATION
mTOR (mechanistic target of rapamycin) is a protein that acts as a central regulator of cell growth, proliferation, and metabolism. It senses nutrient availability, energy status, and growth signals to coordinate cellular responses.
High mTOR activation promotes growth and anabolism but may accelerate aging. Lower mTOR activity (as occurs during fasting or caloric restriction) activates autophagy and is associated with longevity in multiple species.
WHY IT MATTERS
mTOR is a key longevity pathway. Understanding mTOR helps explain why caloric restriction and fasting extend lifespan and improve healthspan.
HOW TO IMPROVE
Balance mTOR activation through periods of protein restriction or fasting, while maintaining adequate protein for muscle health. Timing protein intake strategically.
NORMAL RANGES
mTOR activity is not directly measured clinically. Dietary patterns (fasting, protein restriction) are used to modulate mTOR activity cyclically.
RELATED TERMS
Protein Synthesis
The cellular process of building new proteins, particularly muscle proteins, in response to exercise and nutrition.
NAD+
A coenzyme essential for cellular energy production that declines with age, involved in DNA repair and longevity pathways.
Essential Amino Acids
The nine amino acids that cannot be made by the body and must be obtained through diet.
Autophagy
A cellular process where damaged components are recycled, playing a key role in cellular health and longevity.
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