EARLY ACCESS
Busted

More Vitamins Are Always Better

Supplements | November 30, 2025 | 2 sources

THE CLAIM

"Taking high doses of vitamins is always beneficial and can only help your health."

[EVIDENCE SUMMARY]

Fat-soluble vitamins (A, D, E, K) can accumulate to toxic levels. Even water-soluble vitamins can cause adverse effects at high doses. Mega-dosing provides no additional benefit for most people and may increase health risks. Nutrients from food are generally safer and more effective than high-dose supplements.

The Danger of Fat-Soluble Vitamins

Vitamins A, D, E, and K dissolve in fat and are stored in body tissues. Unlike water-soluble vitamins that are excreted in urine, these can accumulate to dangerous levels. Vitamin A toxicity can cause liver damage, vitamin D excess can lead to dangerous calcium levels.

Even Water-Soluble Vitamins Have Limits

  • Vitamin B6 excess can cause nerve damage
  • Vitamin C mega-doses may cause kidney stones
  • High-dose niacin causes flushing and liver issues
  • Folic acid excess may mask B12 deficiency

The Research Verdict

Large clinical trials have found that vitamin supplements do not reduce mortality in well-nourished populations and may increase risks for certain conditions.

[KEY TAKEAWAYS]

  • More is not better—vitamins have upper tolerable limits
  • Fat-soluble vitamins can accumulate to toxic levels
  • Most people get adequate vitamins from a varied diet
  • Supplements should address specific deficiencies, not exceed needs

[SOURCES] (2)

1

Vitamin and Mineral Supplements: What Clinicians Need to Know

Rautiainen S, et al.

JAMA 2019 High credibility
View source →
2

High-Dose Vitamin Supplement Use

Mayo Clinic High credibility
View source →

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