Grade B
Rct
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Berberine vs Metformin for Glycemic Control: Head-to-Head Trial
Randomized trial comparing berberine to metformin for glucose regulation and metabolic parameters in treatment-naive type 2 diabetics.
Published 2024
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[STUDY DETAILS]
- Study Type
- Rct
- Quality Grade
- B
- Publication Year
- 2024
- Category
- Supplements & Compounds
Summary
12-week RCT (n=116) found berberine (500mg 3x/day) produced comparable HbA1c reductions to metformin (500mg 3x/day): -0.9% vs -1.0%. Berberine showed superior lipid effects.
Key Findings
1. HbA1c reduction comparable to metformin
2. Triglycerides reduced 35% vs 14%
3. LDL reduced 21% vs 8%
4. GI side effects similar between groups