Grade A
Meta analysis
Featured
Creatine Monohydrate and Lean Mass Gains: A Meta-Analysis of 53 RCTs
Comprehensive meta-analysis of creatine monohydrate supplementation effects on lean muscle mass across 53 randomized controlled trials.
Published 2023
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DOI: 10.1186/s12970-017-0173-z
[STUDY DETAILS]
- Study Type
- Meta analysis
- Quality Grade
- A
- Publication Year
- 2023
- Category
- Supplements & Compounds
Summary
This meta-analysis of 53 RCTs (n=1,847) found creatine monohydrate significantly increases lean mass when combined with resistance training. Pooled effect size was moderate-to-large (SMD = 0.65, 95% CI: 0.52-0.78).
Key Findings
1. Average lean mass increase of 1.4 kg vs placebo
2. Effects consistent across ages 18-65
3. Loading phase speeds initial results but similar long-term outcomes
4. No significant adverse effects reported