Grade A
Meta analysis
Omega-3 Fatty Acids and Inflammation: Dose-Response Meta-Analysis
Dose-response meta-analysis of omega-3 supplementation effects on inflammatory markers including CRP, IL-6, and TNF-alpha.
Published 2024
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DOI: 10.1016/j.atherosclerosis.2024.01.015
[STUDY DETAILS]
- Study Type
- Meta analysis
- Quality Grade
- A
- Publication Year
- 2024
- Category
- Supplements & Compounds
Summary
Meta-analysis of 68 RCTs found EPA+DHA supplementation significantly reduces inflammatory markers in dose-dependent manner. Doses >2g/day showed strongest effects on CRP (-0.34 mg/L) and IL-6 (-0.42 pg/mL).
Key Findings
1. CRP reduced by 15-20% at doses >2g/day
2. IL-6 reduced by 12% on average
3. Higher EPA:DHA ratios more anti-inflammatory
4. 8+ weeks needed for significant effects